CP 673,451
货号：
19170-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19170-1mg |
| 描述 | CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor β (PDGFRβ) kinase with an IC50 value of 1 nM.1 It also inhibits the PDGFRα kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2.1 In several in vivo tumor models, CP-673,451 has antiangiogenic and antitumor activity.1,2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Roberts, W.G.,Whalen, P.M.,Soderstrom, E., et al. Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Research 65(3), 957-966 (2005).
2.Xi, Y.,Chen, M.,Liu, X., et al. CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migration. OncoTargets and Therapy 2014:7, 1215-1221 (2014).
3.Ehnman, M.,Missiaglia, E.,Folestad, E., et al. Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments. Cancer Research 73(7), 2139-2149 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 417.5 |
| 分子式 | C24H27N5O2 |
| CAS号 | 343787-29-1 |
| 稳定性 | ≥ 2 years |
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