Bafetinib
货号：
19169-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19169-1mg |
| 描述 | Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib (Item No. 13139), with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM).1 It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo.1 Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.1 |
| 别名 | INNO-406;NS-187; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kimura, S.,Naito, H.,Segawa, H., et al. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia. Blood 106(12), 3948-3954 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 576.6 |
| 分子式 | C30H31F3N8O |
| CAS号 | 859212-16-1 |
| 稳定性 | ≥ 2 years |
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