LLP-3
货号：
19088-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 19088-500ug |
| 描述 | Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins.1,2 LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 µM).3 It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ryan, B.M.,ODonovan, N., and Duffy, M.J. Survivin: A new target for anti-cancer therapy. Cancer Treatment Reviews 35, 553-562 (2009).
2.Shin, S.,Sung, B.J.,Cho, Y.S., et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry 40, 1117-1123 (2001).
3.Guvenc, H.,Pavlyukov, M.S.,Joshi, K., et al. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clinical Cancer Research 19(3), 631-642 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 535 |
| 分子式 | C32H23ClN2O4 |
| CAS号 | 1453835-43-2 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
