BMS 453
货号：
19076-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 19076-1mg |
| 描述 | Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.1 It has been shown to inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1arrest.2 BMS 453 binding to RARα and RARγ can induce a transrepression of phorbol ester-induced AP-1 activity (IC50s = ~0.1 nM in HeLa and MCSF-7 cells), which also correlates with reduced cell proliferation.1 BM 453 has been used to trigger the differentiation of mouse embryonic stem cells (mES) in a study of RARβ-induced mES cell adipogenesis.3 |
| 别名 | BMS 189453; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chen, J.Y.,Penco, S.,Ostrowski, J., et al. RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO Journal 14(6), 1187-1197 (1995).
2.Yang, L.,Ostrowski, J.,Reczek, P., et al. The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFß and causing cell cycle arrest. Oncogene 20(55), 8025-8035 (2001).
3.Monteiro, M.C.,Wdziekonski, B.,Villageois, P., et al. Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptorβand active GSK3. Stem Cells Dev. 18(3), 457-463 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.5 |
| 分子式 | C27H24O2 |
| CAS号 | 166977-43-1 |
| 稳定性 | ≥ 2 years |
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