Nizatidine
货号：
18861-5g 基本售价：
490.0 元 规格：
5 g
产品信息
概述| 货号 | 18861-5g |
| 描述 | Histamine H2 receptors mediate gastric acid secretion by coupling to Gαs proteins and increasing cAMP formation. Nizatidine is a histamine H2 receptor antagonist that decreases gastric acid secretion (ED50 = 0.9 µM in isolated gastric mucosa of bullfrog and ED50s = 1.383 and 0.08 μmol/kg in rats and dogs, respectively).1 Its gastroprotective activity has been exploited in clinical studies of various gastric acid disorders.2,3 |
| 别名 | LY139037; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, T.M.,Evans, D.C.,Warrick, M.W., et al. Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. Journal of Pharmacology and Experimental Therapeutics 239(2), 406-410 (1986).
2.Feldman, M., and Burton, M.E. Histamine2-receptor antagonists. Standard therapy for acid-peptic diseases. (First of two parts). New England Journal of Medicine 323(24), 1672-1680 (1990).
3.Tuskey, A., and Peura, D. The use of H2 antagonists in treating and preventing NSAID-induced mucosal damage. Arthritis Research & Therapy 15(Suppl 3), 1-7 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 331.5 |
| 分子式 | C12H21N5O2S2 |
| CAS号 | 76963-41-2 |
| 稳定性 | ≥ 2 years |
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