Fructose-1,6-bisphosphatase-1 Inhibitor
货号：
18860-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18860-1mg |
| 描述 | Fructose-1,6-bisphosphatase-1 (FBPase-1) is an enzyme that catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, which is one of the rate-limiting steps in gluconeogenesis. Excess hepatic FBPase-1 activity contributes to hyperglycemia in patients. Thus, the development of specific FBPase-1 inhibitors is of great clinical interest for the treatment of patients with type 2 diabetes. FBPase-1 inhibitor is a cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity with an IC50 value of 3.4 µM (Ki = 1.1 µM) by competing at the AMP allosteric binding site.1,2 It has been shown to block glucose production in rat hepatoma cells that are starved of nutrients with an IC50 value of 6.6 µM.1,2 |
| 别名 | F1,6BPase-1 Inhibitor;FBP1 Inhibitor;FBPase-1 Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lai, C.,Gum, R.J.,Daly, M., et al. Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorganic & Medicinal Chemistry Letters 16(7), 1807-1810 (2006).
2.von Geldern, T.W.,Lai, C.,Gum, R.J., et al. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorganic & Medicinal Chemistry Letters 16(7), 1811-1815 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.6 |
| 分子式 | C13H7Cl3N2O3S |
| CAS号 | 883973-99-7 |
| 稳定性 | ≥ 2 years |
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