| 货号 | 18814-1mg |
| 描述 | Regadenoson is a selective, short-acting adenosine A2A receptor agonist (Ki = 1.1 nM for pig striatum A2Areceptor).1,2 It increases coronary blood flow 3.4- to 3.8-fold with a half-time to reversal of 1.9-2.6 minutes in open-chest anesthetized pigs.1 Regadenoson is used to induce hyperemia (increased blood flow), particularly in the context of myocardial perfusion imaging.3,4 It has also been found to increase the delivery of compounds to the central nervous system through the blood-brain barrier in animals.5,6 |
| 别名 | CVT-3146;Lexiscan; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gao, Z.,Li, Z.,Baker, S.P., et al. Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: Inverse relationship between affinity and duration of action of A2A agonists. Journal of Pharmacology and Experimental Therapeutics 298(1), 209-218 (2001). 2.Zhao, G.,Linke, A.,Xu, X., et al. Comparative profile of vasodilation by CVT-3146, a novel A2A receptor agonist, and adenosine in conscious dogs. Journal of Pharmacology and Experimental Therapeutics 307(1), 182-189 (2003). 3.Bhatti, S.,Hakeem, A.,Dhanalakota, S., et al. Prognostic value of regadenoson myocardial single-photon emission computed tomography in patients with different degrees of renal dysfunction. Eur.Heart J.Cardiovasc.Imaging 15(8), 933-940 (2014). 4.Verberne, H.J.,Acampa, W.,Anagnostopoulos, C., et al. EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur.J.Nucl.Med.Mol.Imaging 42(12), 1929-1940 (2015). 5.Carman, A.J.,Mills, J.H.,Krenz, A., et al. Adenosine receptor signaling modulates permeability of the blood-brain barrier. Journal of Neuroscience 31(37), 13272-13280 (2011). 6.Jackson, S.,Anders, N.M.,Mangraviti, A., et al. The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brain. Journal of Neuro-Oncology 126(3), 433-439 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.4 |
| 分子式 | C15H18N8O5 |
| CAS号 | 313348-27-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |