IBTP (iodide)
货号：
18802-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 18802-5mg |
| 描述 | IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner.1 As a result, mitochondrial proteins that have changed thiol redox state following oxidative stress are selectively tagged with IBTP and can be separated by two-dimensional electrophoresis and isolated.1 IBTP-tagged proteins can also be evaluated by immunoblotting using an antibody directed against the triphenylphosphonium moiety of the IBTP molecule.2 IBTP has also been used as a mitochondria-targeted soft electrophile to inhibit mitochondrial oxidative phosphorylation.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, T.-K.,Hughes, G.,Muratovska, A., et al. Specific modification of mitochondrial protein thiols in response to oxidative stress: A proteomics approach. J. Biol. Chem. 277(19), 17048-17056 (2002).
2.Venkatraman, A.,Landar, A.,Davis, A.J., et al. Oxidative modification of hepatic mitochondria protein thiols: Effect of chronic alcohol consumption. Am. J. Physiol. Gastrointest. Liver Physiol. 286(4), G521-G527 (2004).
3.Vayalil, P.K.,Oh, J.-Y.,Zhou, F., et al. A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms. PLoS One 10(3), (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 572.2 |
| 分子式 | C22H23IP • I |
| CAS号 | 159085-21-9 |
| 稳定性 | ≥ 2 years |
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