NIBR189
货号：
18792-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18792-1mg |
| 描述 | Epstein-Barr virus-induced G protein-coupled receptor 2 (EBI2, also known as GPR183) is an oxysterol receptor involved in B cell migration and function.1 NIBR189 is an antagonist of EBI2 (IC50s = 11 and 15 nM for human and mouse receptors, respectively).2 It is selective for EBI2 over a panel of other receptors, enzymes, and transporters. NIBR189 blocks the oxysterol-induced migration of U937 monocytic cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sun, S., and Liu, C. 7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases. Front.Pharmacol. 6:60, (2015).
2.Gessier, F.,Preuss, I.,Yin, H., et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. Journal of Medicinal Chemistry 57, 3358-3368 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429.3 |
| 分子式 | C21H21BrN2O3 |
| CAS号 | 1599432-08-2 |
| 稳定性 | ≥ 2 years |
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