| 货号 | 18750-1mg |
| 描述 | Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml).1,2 Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes.3 Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51).4,5 As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.4,5 |
| 别名 | BMS 207147;ER-30346; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hata, K.,Kimura, J.,Miki, H., et al. In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum. Antimicrobial Agents and Chemotherapy 40(10), 2237-2242 (1996). 2.Hata, K.,Kimura, J.,Miki, H., et al. Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis. Antimicrobial Agents and Chemotherapy 40(10), 2243-2247 (1996). 3.Carillo-Muñoz, A.J.,Giusiano, G.,Ezkurra, P.A., et al. Antifungal agents: mode of action in yeast cells. Rev.Esp.Quimioter. 19(2), 130-139 (2006). 4.Urbina, J.A.,Payares, G.,Sanoja, C., et al. In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease. Int.J.Antimicrob.Agents 21(1), 27-38 (2003). 5.Lepsheva, G.I. Design or screening of drugs for the treatment of Chagas disease: What shows the most promise? Expert Opin.Drug Discov. 8(12), 1479-1489 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 437.5 |
| 分子式 | C22H17F2N5OS |
| CAS号 | 182760-06-1 |
| 稳定性 | ≥ 2 years |
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