| 货号 | 18718-1mg |
| 描述 | RWJ 67657 is an orally active inhibitor of the MAP kinases p38α and p38β (IC50s = 1 and 11 µM, respectively, in vitro) that is inactive against p38γ and p38δ, as well as several other kinases.1 It blocks the release of TNF-α and IL-1β from peripheral blood mononuclear cells stimulated with LPS (IC50s = 3 and 11 nM, respectively) and inhibits TNF-α production in LPS-treated mice and rats.1 RWJ 67657 potently blocks the proliferation of CD4+ peripheral blood T cells induced by CD28 stimulation alone (IC50 = 0.5-4 nM).2 It is commonly used to study the roles of p38α and p38β in cellular and whole animal systems.3,4,5 |
| 别名 | JNJ-3026582; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wadsworth, S.A.,Cavender, D.E.,Beers, S.A., et al. RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. Journal of Pharmacology and Experimental Therapeutics 291(2), 680-687 (1999). 2.Schafer, P.H.,Wadsworth, S.A.,Wang, L., et al. p38 α mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+ CD45RO+ T cells and Th2 effector cells. Journal of Immunology 162(12), 7110-7119 (2016). 3.Kompa, A.R.,See, F.,Lewis, D.A., et al. Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction. Journal of Pharmacology and Experimental Therapeutics 325(3), 741-750 (2008). 4.Antoon, J.W.,Nitzchke, A.M.,Martin, E.C., et al. Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transition. International Journal of Oncology 42(4), 1139-1150 (2013). 5.Bai, Y.Y.,Wang, L.,Chang, D., et al. Synergistic effects of transplanted endothelial progenitor cells and RWJ 67657 in diabetic ischemic stroke models. Stroke 46(7), 1938-1946 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 425.5 |
| 分子式 | C27H24FN3O |
| CAS号 | 215303-72-3 |
| 稳定性 | ≥ 2 years |
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