ITSA1
货号：
18681-10mg 基本售价：
490.0 元 规格：
10 mg
产品信息
概述| 货号 | 18681-10mg |
| 描述 | Trichostatin A (TSA; Item No. 89730) is a potent, reversible inhibitor of histone deacetylase (HDAC) that inhibits HDAC1 (IC50 = 70 nM) in Jurkat cells, resulting in cell cycle arrest.1 ITSA1 is a cell-permeable benzotriazole amide that blocks TSA action, reducing TSA-induced acetylation of histone and tubulin in A549 cells when given at 50 µM.2 At the same concentration, ITSA1 also prevents TSA-mediated cell cycle arrest and apoptosis.2 It similarly blocks the action of the HDAC inhibitor SAHA (Item No. 10009929), preventing SAHA-induced hyperacetylation of tubulin in A549 cells.2 ITSA1 reduces TSA-regulated transcription in mouse embryonic stem cells and in zebrafish.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hoshikawa, Y.,Kwon, H.J.,Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Experimental Cell Research 214, 189-197 (1994).
2.Koeller, K.M.,Haggarty, S.J.,Perkins, B.D., et al. Chemical genetic modifier screens: Small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chemistry & Biology 10(5), 397-410 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 292.1 |
| 分子式 | C13H7Cl2N3O |
| CAS号 | 200626-61-5 |
| 稳定性 | ≥ 2 years |
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