| 货号 | 18674-10g |
| 描述 | Diphenidol is a non-selective muscarinic acetylcholine receptor antagonist.1 It is also a non-specific inhibitor of voltage-gated ion channels (Na+, K+, and Ca2+) in neurons.2 Diphenidol has been used to inhibit rotation-induced firing of type 1 medial vestibular nucleus neurons in a cat model of vertigo and to block the chemoreceptor trigger zone in the medulla that controls apomorphine-induced vomiting in a dog model of emesis.3,4 |
| 别名 | SKF 478A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Soto, E., and Vega, R. Neuropharmacology of vestibular system disorders. Curr. Neuropharmacol. 8(1), 26-40 (2010). 2.Leung, Y.M.,Wong, K.L.,Cheng, K.S., et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacological Reports 64(3), 739-744 (2012). 3.Kawabata, A.,Sasa, M.,Kishimoto, T., et al. Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotation. Japanese Journal of Pharmacology 55(1), 101-106 (1991). 4.Nakayama, H.,Yamakuni, H.,Nakayama, A., et al. Diphenidol has no actual broad antiemetic activity in dogs and ferrets. Journal of Pharmacological Sciences 96(3), 301-306 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 345.9 |
| 分子式 | C21H27NO • HCl |
| CAS号 | 3254-89-5 |
| 稳定性 | ≥ 2 years |
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