| 货号 | 18630-1mg |
| 描述 | Propranolol inhibits β1-, β2-, and β3-adrenergic receptors with log KD values of -8.16, -9.08, and -6.93, respectively.1,2 (±)-4-hydroxy Propranolol is an active metabolite of propranolol, inhibiting β1- and β2-adrenergic receptors with KD values of 2.4 and 5.8 nM, respectively.3,4 It is comparable to propranolol in potency in antagonizing the effects of isoprenaline on heart rate and blood pressure in cats and dogs.3,5 (±)-4-hydroxy Propranolol also has antioxidant properties at micromolar concentrations.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 2.Mehvar, R., and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001). 3.Fitzgerald, J.D., and ODonnell, S.R. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. British Journal of Pharmacology 43(1), 222-235 (1971). 4.Nelson, W.L.,Bartels, M.J.,Bednarski, P.J., et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. Journal of Medicinal Chemistry 27(7), 857-861 (1984). 5.Fitzgerald, J.D., and ODonnell, S.R. A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogs. British Journal of Pharmacology 45(2), 207-217 (1972). 6.Mak, I.T., and Weglicki, W.B. Potent antioxidant properties of 4-hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics 308(1), 85-90 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 311.8 |
| 分子式 | C16H21NO3 • HCl |
| CAS号 | 14133-90-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |