| 货号 | 18622-1mg |
| 描述 | BRL 37344 is a selective agonist of β3-adrenergic receptors with Ki values of 0.43, 9.17, and 37.9 µM for β3, β2, and β1, respectively.1β3-Adrenoceptors are expressed in adipose tissue as well as endothelial and myocardial tissues.2 This compound has been used to explore the role of these receptors in the regulation of thermogenesis and lipolysis and to modulate cardiac function in models of cardiovascular disease.3 It has also been used in rodents to study the role that β3-adrenergic receptors play in regulating anxiety-like behaviors.4 |
| 别名 | BRL 37344A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hoffmann, C.,Leitz, M.R.,Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedebergs Arch. Pharmacol. 369(2), 151-159 (2004). 2.Kanzler, S.A.,Januario, A.C., and Paschoalini, M.A. Involvement of β3-adrenergic receptors in the control of food intake in rats. Brazilian Journal of Medical and Biological Research 44(11), 1141-1147 (2011). 3.Niu, X.,Zhao, L.,Li, X., et al. β3-Adrenoreceptor stimulation protects against myocardial infarction injury via eNOS and nNOS activation. PLoS One 9(6), (2014). 4.Butler, T.R.,Chappell, A.M., and Weiner, J.L. Effect of β3 adrenoceptor activation in the basolateral amygdala on ethanol seeking behaviors. Psychopharmacology (Berl) 231(1), 293-303 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 385.8 |
| 分子式 | C19H21ClNO4 • Na |
| CAS号 | 127299-93-8 |
| 稳定性 | ≥ 2 years |
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