2-Aminopurine (hydrochloride)
货号：
18609-50mg 基本售价：
490.0 元 规格：
50 mg
产品信息
概述| 货号 | 18609-50mg |
| 描述 | 2-Aminopurine is a fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics.1 It base pairs with cytosine in a wobble configuration or with thymine in a Watson–Crick geometry.1 In addition to its usefulness in studies of base stacking interactions, 2-aminopurine has been used as a probe for DNA base flipping by methyl transferases.2 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase, protein kinase R, whose activity mediates antiviral defense and participates in toll-like receptor signaling.3 |
| 别名 | 2-AP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jean, J.M., and Hall, K.B. 2-Aminopurine fluorescence quenching and lifetimes: Role of base stacking. Proc.Nat.Acad.Sci.USA 98(1), 37-41 (2001).
2.Holz, B.,Klimasauskas, S.,Serva, S., et al. 2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases. Nucleic Acids Research 26(4), 1076-1083 (1998).
3.Endoh, Y.,Chung, Y.M.,Clark, I.A., et al. IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA. Journal of Immunology 182(4), 2258-2268 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 208.1 |
| 分子式 | C5H5N5 • 2HCl |
| CAS号 | 1428126-74-2 |
| 稳定性 | ≥ 2 years |
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