| 货号 | 18600-1g |
| 描述 | γ-Aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. (±)-Baclofen is a selective agonist of GABAB(IC50 = 200 nM).1 By activating GABAB, (±)-baclofen causes skeletal muscle relaxation and blocks spasticity.2,3,4 It also modifies animal responses to alcohol and cocaine.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Berthelot, P.,Vaccher, C.,Musadad, A., et al. Synthesis and pharmacological evaluation of gamma-aminobutyric acid analogues. New ligand for GABAB sites. Journal of Medicinal Chemistry 30(4), 743-746 (1987). 2.Biscoe, T.J., and Fry, J.P. Some pharmacological studies on the spastic mouse. British Journal of Pharmacology 75(1), 23-25 (1982). 3.Sakitani, K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats. Japanese Journal of Pharmacology 63(3), 369-376 (1993). 4.Chou, R.,Peterson, K., and Helfand, M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic review. Journal of Pain and Symptom Management 28(2), 140-175 (2004). 5.Moore, E.M., and Boehm, S.L., II. Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice. Behav.Neurosci. 123(3), 555-563 (2009). 6.Lhuillier, L.,Mombereau, C.,Cryan, J.F., et al. GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. Neuropsychopharmacology 32(2), 388-398 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 213.7 |
| 分子式 | C10H12ClNO2 |
| CAS号 | 1134-47-0 |
| 稳定性 | ≥ 2 years |
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