| 货号 | 18525-1mg |
| 描述 | BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein.1 It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes.1,2,3 BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.4 |
| 别名 | BMS-378806; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Guo, Q.,Ho, H.T.,Dicker, I., et al. Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions. Journal of Virology 77(19), 10528-10536 (2003). 2.Madani, N.,Perdigoto, A.L.,Srinivasan, K., et al. Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155. Journal of Virology 78(7), 3742-3752 (2004). 3.Si, Z.,Madani, N.,Cox, J.M., et al. Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proceedings of the National Academy of Sciences of the United States of America 101(14), 5036-5041 (2004). 4.Lin, P.F.,Blair, W.,Wang, T., et al. A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. Proceedings of the National Academy of Sciences of the United States of America 100(19), 11013-11018 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 406.4 |
| 分子式 | C22H22N4O4 |
| CAS号 | 357263-13-9 |
| 稳定性 | ≥ 2 years |
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