| 货号 | 18514-50mg |
| 描述 | Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.1,2 It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.3,4 |
| 别名 | (-)-BCH 189;Epivir™;Epivir-HBV™;3TC;2’,3’-dideoxy-3’-Thiacytidine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Perez-Olmeda, M.,Garcia-Perez, J.,Mateos, E., et al. In vitro analysis of synergism and antagonism of different nucleoside/nucleotide analogue combinations on the inhibition of human immunodeficiency virus type 1 replication. J.Med.Virol. 81(2), 211-216 (2008). 2.Keeffe, E.B., and Marcellin, P. New and emerging treatment of chronic hepatitis B. Clin.Gastroenterol.Hepatol. 5(3), 285-294 (2007). 3.Ma, Z.J.,Li, Q.,Wang, J.B., et al. Combining oxymatrine or matrine with lamivudine increased its antireplication effect against the hepatitis B virus in vitro. Evidence-Based Complementary and alternative Medicine 2013, 186573 (2013). 4.Robinson, B.S.,Riccardi, K.A.,Gong, Y.F., et al. BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents. Antimicrobial Agents and Chemotherapy 44(8), 2093-2099 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 229.3 |
| 分子式 | C8H11N3O3S |
| CAS号 | 134678-17-4 |
| 稳定性 | ≥ 2 years |
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