R788 (sodium salt)
货号：
18501-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18501-1mg |
| 描述 | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. R788 is a prodrug of R406 (Item No. 11422), an inhibitor of Syk (Ki = 30 nM).1 R788 conversion to the biologically active R406 is catalyzed by the action of alkaline phosphatases present on the apical brush-border of the membranes of intestinal enterocytes.1 It produces anti-inflammatory and immunomodulating effects by inhibiting Syk-mediated IgG Fcγ receptor signaling, which prevents activation of mast cells, macrophages, and B cells, as well as related inflammatory responses.1 R788 has undergone clinical evaluation for efficacy in the treatment of rheumatoid arthritis.1 |
| 别名 | Fostamatinib;NSC 745942;R935788;Tamatinib Fosdium; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Singh, R.,Masuda, E.S., and Payan, D.G. Discovery and development of spleen tyrosine kinase (SYK) inhibitors. Journal of Medicinal Chemistry 55(8), 3614-3643 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 624.4 |
| 分子式 | C23H24FN6O9P • 2Na |
| CAS号 | 1025687-58-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
