EMD 1214063
货号：
18492-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18492-1mg |
| 描述 | MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. EMD 1214063 inhibits c-Met with an IC50 value of 3 nM, demonstrating at least 1,000-fold selectivity for c-Met over a panel of 242 additional kinases.1 It has been shown to inhibit c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50s = 6-9 nM) and, at 5-15 mg/kg, to regress tumors in mouse xenograft models.1 |
| 别名 | Tepotinib;MSC2156119; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bladt, F.,Faden, B.,Friese-Hamim, M., et al. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clinical Cancer Research 19(11), 2941-2951 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 492.6 |
| 分子式 | C29H28N6O2 |
| CAS号 | 1100598-32-0 |
| 稳定性 | ≥ 2 years |
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