NVP-BHG712
货号：
18489-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18489-1mg |
| 描述 | The EphB4 receptor tyrosine kinase (cloned from erythropoietin-producing hepatocellular carcinoma) and its ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. Signaling from this pair is also involved in tumor angiogenesis. NVP-BHG712 is an orally bioavailable inhibitor of EphB4 kinase autophosphorylation (ED50 = 25 nM).1 It is selective for EphB4, demonstrating an ED50 value of 4.2 µM at the related VEGFR2 receptor and ED50 values >10 µM against a panel of 40 additional kinases.1 At 3-30 mg/kg, NVP-BHG712 dose dependently inhibits VEGF-directed vessel formation in an in vivo mouse model of angiogenesis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martiny-Baron, G.,Holzer, P.,Billy, E., et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis 13, 259-267 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 503.5 |
| 分子式 | C26H20F3N7O |
| CAS号 | 940310-85-0 |
| 稳定性 | ≥ 2 years |
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