SBI-0206965
货号：
18477-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18477-1mg |
| 描述 | ULK1 is a serine/threonine kinase that acts upstream of phosphatidylinositol 3-kinase (PI3K) to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation. It is activated by phosphorylation by AMPK and, in turn, phosphorylates and inhibits AMPK. SBI-0206965 is an inhibitor of ULK1 (IC50 = 108 nM) that is less effective against ULK2 (IC50 = 711 nM).1 It is selective for ULK1 and ULK2 over a panel of 456 additional kinases, showing activity against a few kinases in vitro but not in cells.1 SBI-0206965 suppresses autophagy induced by mTOR inhibition via AZD 8055 (Item No. 16978). It also blocks ULK1-dependent cell survival following nutrient deprivation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Egan, D.F.,Chun, M.G.H.,Vamos, M., et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Molecular Cell 59, 285-297 (2015).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 489.3 |
| 分子式 | C21H21BrN4O5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
