4E1RCat
货号：
18399-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18399-1mg |
| 描述 | 4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.1 It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.1 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.1 |
| 别名 | eIF4E/eIF4G Interaction Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cencic, R.,Hall, D.R.,Robert, F., et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proceedings of the National Academy of Sciences of the United States of America 108(3), 1046-1051 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 478.5 |
| 分子式 | C28H18N2O6 |
| CAS号 | 328998-25-0 |
| 稳定性 | ≥ 2 years |
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