MLN9708
货号：
18386-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18386-1mg |
| 描述 | MLN9708 is an orally bioavailable prodrug of the second-generation proteasome inhibitor MLN2239 (Item No. 18385).1,2 This prodrug rapidly hydrolyzes in plasma to the biologically active form, which inhibits the β5 chymotryptic-like subunit of the 20S proteasome (IC50 = 3.4 nM; Ki = 0.93 nM in cell-free assays).1,2 It inhibits the β1 caspase-like and β2 trypsin-like proteolytic sites with IC50 values of 0.03 and 3.5 µM, respectively.1 MLN9708 has shown antitumor activity both in cell-based assays and in xenograft models and has been examined in phase III clinical trials for potential antimyeloma activity.1,2 |
| 别名 | Ixazomib Citrate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kupperman, E.,Lee, E.C.,Cao, Y., et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Research 70(5), 1970-1980 (2010).
2.Garcia-Gomez, A.,Quwaider, D.,Canavese, M., et al. Preclinical activity of the oral proteasome inhibitor MLN9708 in Myeloma bone disease. Clinical Cancer Research 20(6), 1542-1554 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 517.1 |
| 分子式 | C20H23BCl2N2O9 |
| CAS号 | 1201902-80-8 |
| 稳定性 | ≥ 2 years |
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