AEM1
货号：
18321-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 18321-500ug |
| 描述 | Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation.1 AEM1 is an inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 µM.2 It sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitroandin vivo in animals.2 The effectiveness of AEM1 against cancer cells is restricted to those harboring mutations that render Nrf2 constitutively active.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.DeNicola, G.M.,Karreth, F.A.,Humpton, T.J., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475(7354), 106-109 (2011).
2.Bollong, M.J.,Yun, H.,Sherwood, L., et al. A small molecule inhibits deregulated NRF2 transcriptional activity in cancer. ACS Chemical Biology 10(10), 2193-2198 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.4 |
| 分子式 | C20H14FN3O2S |
| CAS号 | 1030123-90-0 |
| 稳定性 | ≥ 2 years |
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