Gestodene
货号：
18217-50mg 基本售价：
490.0 元 规格：
50 mg
产品信息
概述| 货号 | 18217-50mg |
| 描述 | Progesterone (Item No. 15876) is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Gestodene is a synthetic progesterone analog (i.e., a progestin) that is structurally related to testosterone (Item No. 15645). A USP-approved grade of gestodene is often formulated in combination with ethynyl estradiol (Item No. 10006486) and provided for use as an oral contraceptive.1,2 Gestodene offers a pharmacokinetic advantage over the other progestins in that it is directly active (the others are prodrugs), has high bioavailability, and is androgenically neutral.1 Gestodene does not bind the estrogen receptor (ER); however, two of its A-ring metabolites can bind ER and possess weak estrogenic activity.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stanczyk, F.Z. All progestins are not created equal. Steroids 68, 879-890 (2003).
2.Heger-Mahn, D.,Warlimont, C.,Faustmann, T., et al. Combined ethinylestradiol/gestodene contraceptive patch: Two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers. Eur.J.Contracept.Reprod.Health Care 9(3), 173-181 (2004).
3.Lemus, A.E.,Zaga, V.,Santillán, R., et al. The oestrogenic effects of gestodene, a potent contraceptive progestin, are mediated by its A-ring reduced metabolites. Journal of Endocrinology 165, 693-702 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 310.4 |
| 分子式 | C21H26O2 |
| CAS号 | 60282-87-3 |
| 稳定性 | ≥ 2 years |
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