SCH 900776
货号：
18131-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 18131-500ug |
| 描述 | Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).1 In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.1 At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitroandin vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.1 |
| 别名 | MK-8776; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Guzi, T.J.,Paruch, K.,Dwyer, M.P., et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Molecular Cancer Therapeutics 10(4), 591-602 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 376.3 |
| 分子式 | C15H18BrN7 |
| CAS号 | 891494-63-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
