| 货号 | 18041-1g |
| 描述 | Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.1,2 Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.3 Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.4 |
| 别名 | Gerontine;Musculamine;Neuridine;NSC 268508;1,5,10,14-Tetraazatetradecane; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wallace, H.M.,Fraser, A.V., and Hughes, A. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003). 2.Igarashi, K., and Kashiwagi, K. Polyamines: Mysterious modulators of cellular functions. Biochemical and Biophysical Research Communications 271(3), 559-564 (2000). 3.Williams, K. Interactions of polyamines with ion channels. Biochemistry Journal 325, 289-297 (1997). 4.Ha, H.C.,Sirisoma, N.S.,Kuppusamy, P., et al. The natural polyamine spermine functions directly as a free radical scavenger. Proceedings of the National Academy of Sciences of the United States of America 95, 11140-11145 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 202.3 |
| 分子式 | C10H26N4 |
| CAS号 | 71-44-3 |
| 稳定性 | ≥ 2 years |
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