K-Ras(G12C) Inhibitor 9
货号：
18005-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18005-1mg |
| 描述 | K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.1 K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.2,3 Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ostrem, J.M.,Peters, U.,Sos, M.L., et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503(7477), 548-551 (2013).
2.Lim, S.M.,Westover, K.D.,Ficarro, S.B., et al. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angewandte Chemistry International Edition English 53(1), 199-204 (2014).
3.Padavano, J.,Henkhaus, R.S.,Chen, J., et al. Mutant K-RAS promotes invasion and metastasis in pancreatic cancer through GTPase signaling pathways. Cancer Growth Metastasis 8 (suppl 1), 95-113 (2015).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 513.8 |
| 分子式 | C16H21ClIN3O4S |
| CAS号 | 1469337-91-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
