| 货号 | 18001-5mg |
| 描述 | FH535 is an inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ.1 At 15 µM, FH535 blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ.1 Presumably through these actions, FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway.1 FH535 is used to study the role of Wnt/β-catenin pathway in various cancer cell lines.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Handeli, S., and Simon, J.A. A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Molecular Cancer Therapeutics 7(3), 521-529 (2008). 2.Faisy, C.,Grassin-Delyle, S.,Blouquit-Laye, S., et al. Wnt/ß-catenin signaling modulates human airway sensitization induced by ß2-adrenoceptor stimulation. PLoS One 9(10), (2014). 3.Su, H.,Jin, X.,Zhang, X., et al. FH535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line KYSE-150R. Journal of Translational Medicine 13:104, (2015). 4.Wu, M.Y.,Liang, R.R.,Chen, K., et al. FH535 inhibited metastasis and growth of pancreatic cancer cells. OncoTargets and Therapy 8, 1651-1670 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 361.2 |
| 分子式 | C13H10Cl2N2O4S |
| CAS号 | 108409-83-2 |
| 稳定性 | ≥ 2 years |
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