CZC-54252
货号：
17998-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17998-1mg |
| 描述 | CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively).1 It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in primary human neurons with an EC50 value of 1 nM.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kramer, T.T.,Monte, F.L.,Göring, S., et al. Small molecule kinase inhibitors for LRRK2 and their application to Parkinson’s disease models. ACS Chem. Neurosci. 3(3), 151-160 (2012).
2.Ramsden, N.G.,Perrin, J.,Ren, Z., et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson’s disease-related toxicity in human neurons. ACS Chem Biol. 6(10), 1021-1028 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 505 |
| 分子式 | C22H25ClN6O4S |
| CAS号 | 1191911-27-9 |
| 稳定性 | ≥ 2 years |
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