Afuresertib (hydrochloride)
货号：
17988-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17988-1mg |
| 描述 | Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively.1 It preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies with minimal effect on glucose homeostasis.1 Afuresertib demonstrates activity against multiple myeloma in both preclinical and clinical models.1,2 |
| 别名 | GSK2110183B; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dumble, M.,Crouthamel, M.C.,Zhang, S.Y., et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One 9(6), (2014).
2.Spencer, A.,Yoon, S.S.,Harrison, S.J., et al. The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood 124(14), 2190-2195 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 463.8 |
| 分子式 | C18H17Cl2FN4OS • HCl |
| CAS号 | 1047645-82-8 |
| 稳定性 | ≥ 2 years |
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