| 货号 | 17908-50mg |
| 描述 | (±)-Nicotine (Item No. 16535) is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.1 Myosmine is a minor tobacco alkaloid that is structurally related to nicotine. It can also be found in a variety of other plants that are commonly eaten, including maize, rice, and potato.2 Myosmine weakly binds to neuronal acetylcholine receptors (Ki = 3.3 µM).3 However, it can be nitrosated, giving rise to a DNA adduct.2,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zaveri, N.,Jiang, F.,Olsen, C., et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. Journal of Medicinal Chemistry 53, 8187-8191 (2010). 2.Tyroller, S.,Zwickenpflung, W., and Richter, E. New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milk. Journal of Agricultural and Food Chemistry 50(17), 4909-4915 (2002). 3.Ferretti, G.,Dukat, M.,Giannella, M., et al. Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors. Bioorganic & Medicinal Chemistry Letters 13(4), 733-735 (2003). 4.Zwickenpflung, W.,Tyroller, S., and Richter, E. Metabolism of myosmine in wistar rats. Drug Metabolism and Disposition 33, 1648-1656 (2005). 5.Hecht, S.S.,Han, S.,Kenney, P.M.J., et al. Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. Chemical Research in Toxicology 20(3), 543-549 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 146.2 |
| 分子式 | C9H10N2 |
| CAS号 | 532-12-7 |
| 稳定性 | ≥ 2 years |
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