SNS-032
货号：
17904-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17904-1mg |
| 描述 | Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively.1 It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM).1 SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 µM.2 This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.3 |
| 别名 | BMS-387032; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Misra, R.N.,Xiao, H.Y.,Kim, K.S., et al. N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. Journal of Medicinal Chemistry 47(7), 1719-1728 (2004).
2.Conroy, A.,Stockett, D.E.,Walker, D., et al. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemotherapy and Pharmacology 64, 723-732 (2009).
3.Chen, R.,Wierda, W.G.,Chubb, S., et al. Mechanism of action of SNS032, a novel cyclindependent kinase inhibitor, in chronic lymphocytic leukemia. Blood 113(19), 4637-4645 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.5 |
| 分子式 | C17H24N4O2S2 |
| CAS号 | 345627-80-7 |
| 稳定性 | ≥ 2 years |
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