Liproxstatin-1
货号：
17730-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17730-1mg |
| 描述 | Ferroptosis is a regulated, non-apoptotic form of cell death involving the production of iron-dependent reactive oxygen species (ROS).1 Glutathione peroxidase 4 (Gpx4) is an essential regulator of ferroptotic cell death, playing a critical role in preventing ROS-induced lipid peroxidation.2 Liproxstatin-1 is an inhibitor of ferroptosis induced in mouse embryonic fibroblasts (MEFs) by Gpx4 deletion (IC50 = 22 nM).3 It does not interfere with apoptosis, necroptosis, or necrosis. Liproxstatin-1 also blocks ferroptosis induced by specific ferroptosis inducers, including the glutathioine-depleting agents BSO and erastin and the Gpx4 inhibitor RSL3.3 It is effective in vivo when administered intraperitoneally, suppressing ferroptosis in Gpx4-/- mice and in a mouse model of ischemia/reperfusion-induced liver injury.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dixon, S.J.,Lemberg, K.M.,Lamprecht, M.R., et al. Ferroptosis: An iron-dependent form of non-apoptotic cell death. Cell 149(5), 1060-1072 (2012).
2.Yang, W.S.,SriRamaratnam, R.,Welsch, M.E., et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156(1-2), 317-313 (2015).
3.Friedmann Angeli, J.P.,Schneider, M.,Proneth, B., et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 16(12), 1180-1191 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 340.9 |
| 分子式 | C19H21ClN4 |
| CAS号 | 950455-15-9 |
| 稳定性 | ≥ 2 years |
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