PND1186
货号：
17668-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17668-1mg |
| 描述 | PND1186 is a potent reversible focal adhesion kinase (FAK) inhibitor with an IC50 value of 1.5 nM against the recombinant enzyme and 100 nM in breast carcinoma cells.1 It promotes 4T1 breast carcinoma and ID8 ovarian carcinoma cell apoptosis when grown in anchorage-independent 3D cultures but had limited efficacy in 2D cultures. It is orally bioavailable, reducing orthotopic breast cancer tumor growth in mouse models.2 |
| 别名 | SR 2516;VS-4718; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tanjoni, I.,Walsh, C.,Uryu, S., et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol. Ther. 9(10), 764-777 (2010).
2.Walsh, C.,Tanjoni, I.,Uryu, S., et al. Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol. Ther. 9(10), 778-790 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 501.5 |
| 分子式 | C25H26F3N5O3 |
| CAS号 | 1061353-68-1 |
| 稳定性 | ≥ 2 years |
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