APD668
货号：
17642-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17642-1mg |
| 描述 | GPR119, a glucose-dependent insulinotropic receptor, is a G protein-coupled receptor that is expressed in pancreatic β-cells and intestinal L-cells.1 Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine (Item No. 10172) and oleoyl ethanolamide (Item No. 90265) increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion.1,2 APD668 is a potent agonist of GPR119 (EC50s = 2.7 and 33 nM for human and rat forms, respectively).3 Chronic dosing with APD668 in Zucker diabetic fatty rats over several weeks significantly reduces blood glucose and glycated hemoglobin levels.3 |
| 别名 | JNJ-28630368; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Overton, H.A.,Babbs, A.J.,Doel, S.M., et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metabolism 3, 167-175 (2006).
2.Soga, T.,Ohishi, T.,Matsui, T., et al. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochemical and Biophysical Research Communications 326, 744-751 (2005).
3.Semple, G.,Ren, A.,Fioravanti, B., et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorganic & Medicinal Chemistry Letters 21(10), 3134-3141 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.5 |
| 分子式 | C21H24FN5O5S |
| CAS号 | 832714-46-2 |
| 稳定性 | ≥ 2 years |
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