ML-184
货号：
17641-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 17641-500ug |
| 描述 | GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI).1,2 ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 µM).3 It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2(IC50s = 21.8 and 15.1 µM, respectively).3 Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.3 |
| 别名 | CID-2440433; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ryberg, E.,Larsson, N.,Sjögren, S., et al. The orphan receptor GPR55 is a novel cannabinoid receptor. British Journal of Pharmacology 152, 1092-1101 (2007).
2.Oka, S.,Nakajima, K.,Yamashita, A., et al. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochemical and Biophysical Research Communications 362, 928-934 (2007).
3.Kotsikorou, E.,Madrigal, K.E.,Hurst, D.P., et al. Identification of the GPR55 agonist binding site using a novel set of high potency GPR55 selective ligands. Biochemistry 50(25), 5633-5647 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470.6 |
| 分子式 | C25H34N4O3S |
| CAS号 | 794572-10-4 |
| 稳定性 | ≥ 2 years |
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