Enalaprilat (hydrate)
货号：
17603-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 17603-5mg |
| 描述 | Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril (Item No. 16041), an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.1. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Redelinghuys, P.,Nchinda, A.T., and Sturrock, E.D. Development of domain-selective angiotensin I-converting enzyme inhibitors. Annals of the New York Academy of Sciences 1056, 160-175 (2005).
2.Mencel, J.J.,Regan, J.R.,Barton, J., et al. Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives. Journal of Medicinal Chemistry 33(6), 1606-1615 (1990).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 384.4 |
| 分子式 | C18H24N2O5 • 2H2O |
| CAS号 | 84680-54-6 |
| 稳定性 | ≥ 2 years |
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