Galeterone
货号：
17586-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17586-1mg |
| 描述 | The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids.1 Galeterone is a CYP17 inhibitor (IC50 = 300 nM) that has been shown to competitively block synthetic androgen binding (EC50 = 845 nM) and to antagonize the androgen receptor in transcriptional activation assays.2 Galeterone can inhibit the growth of castration-resistant prostate cancer cells with an IC50 value of 2.9 µM and demonstrates synergy with everolimus (Item No. 11597) or gefitinib (Item No. 13166) for growth inhibition.2,3 |
| 别名 | TOK-001; |
性能| 供应商 | Cayman |
| 应用文献 |
1.ODonnell, A.,Judson, I.,Dowsett, M., et al. Hormonal impact of the 17α-hydroxylase/C17,20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. British Journal of Cancer 90(12), 2317-2325 (2004).
2.Njar, V.C.O., and Brodie, A.M.H. Discovery and development of galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer. Journal of Medicinal Chemistry 58(5), 2077-2087 (2015).
3.Gupta, E.,Guthrie, T., and Tan, W. Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC). BMC Urol. 14, 1-8 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.6 |
| 分子式 | C26H32N2O |
| CAS号 | 851983-85-2 |
| 稳定性 | ≥ 2 years |
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