| 货号 | 17550-5g |
| 描述 | N-4-Tosyl-L-arginine methyl ester (TAME) is a synthetic substrate of serine proteases, including thrombin, trypsin, chymotrypsin, and kallikreins.1,2,3 It can be used to evaluate serine proteases from diverse sources.4 TAME also binds to and inhibits anaphase-promoting complex, a ubiquitin ligase, in Xenopus egg extract.5,6 |
| 别名 | TAME;Tosylarginine methyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hummel, B.C. A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. Canadian Journal of Biochemistry and Physiology 37, 1393-1399 (1959). 2.Matsuda, Y.,Miyazaki, K.,Moriya, H., et al. Purification and characterization of human urinary kallikreins. Journal of Biochemistry 80(4), 671-679 (1976). 3.Esmon, C.T.,Esmon, N.L., and Harris, K.W. Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. The Journal of Biological Chemisty 257(14), 7944-7947 (1982). 4.Morgado-Díaz, J.A.,da Silvia-Lopez, R.E.,Alves, C.R., et al. Subcellular localization of an intracellular serine protease of 68 kDa in Leishmania (Leishmania) amazonensis promastigotes. Mem.Inst.Oswaldo Cruz 100(4), 377-383 (2005). 5.Zeng, X.,Sigoillot, F.,Gaur, S., et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 18(4), 382-395 (2010). 6.Zeng, X., and King, R.W. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nature Chemical Biology 8(4), 383-392 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 378.9 |
| 分子式 | C14H22N4O4S • HCl |
| CAS号 | 1784-03-8 |
| 稳定性 | ≥ 2 years |
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