Isradipine
货号：
17536-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 17536-5mg |
| 描述 | Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity.1 It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria.1 By suppressing calcium influx into the cytoplasm and Cav1.2 expression, isradipine has been shown to attenuate β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease.2 |
| 别名 | PN 200-110; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hof, R.P.,Scholtysik, G.,Loutzenhiser, R., et al. PN 200-110, a new calcium antagonist: Electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. Journal of Cardiovascular Pharmacology 6(3), 399-406 (1984).
2.Anekonda, T.S., and Quinn, J.F. Calcium channel blocking as a therapeutic strategy for Alzheimer’s disease: The case for isradipine. Biochimica et Biophysica Acta 1812(12), 1584-1590 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.4 |
| 分子式 | C19H21N3O5 |
| CAS号 | 75695-93-1 |
| 稳定性 | ≥ 2 years |
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