AR420626
货号：
17531-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 17531-500ug |
| 描述 | Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.1 AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.2 At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Inoue, D.,Tsujimoto, G., and Kimura, I. Regulation of energy homeostasis by GPR41. Front.Endocrinol.(Lausanne) 5, 1-3 (2014).
2.Engelstoft, M.S.,Park, W.m.,Sakata, I., et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol.Metab. 2(4), 376-392 (2013).
3.Nohr, M.K.,Pedersen, M.H.,Gille, A., et al. GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology 154(10), 3552-3564 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 417.3 |
| 分子式 | C21H18Cl2N2O3 |
| CAS号 | 1798310-55-0 |
| 稳定性 | ≥ 2 years |
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