DBIBB
货号：
17529-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17529-1mg |
| 描述 | The lysophosphatidic acid (LPA) receptor LPA2 is a G protein-coupled receptor that has roles in protecting against radiation-induced cell death.1 DBIBB is a non-lipid agonist of LPA2(EC50 = 0.10 µM) that is without effect at other LPA receptor subtypes.2 It protects rat intestinal crypt epithelium-like IEC-6 cells against caspase 3/7 activation and apoptosis following irradiation.2 DBIBB dose-dependently attenuates radiation-induced DNA damage in mouse embryo fibroblasts (MEFs) expressing LPA2 but not in MEFs lacking this receptor.2 It also increases the survival of mice suffering from hematopoietic acute radiation syndrome after total-body irradiation.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, F.T.,Lai, Y.J.,Makarova, N., et al. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. The Journal of Biological Chemisty 282(52), 37759-37769 (2007).
2.Patil, R.,Szabó, E.,Fells, J.I., et al. Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist. Chemistry & Biology 22, 206-216 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 452.5 |
| 分子式 | C23H20N2O6S |
| CAS号 | 1569309-92-7 |
| 稳定性 | ≥ 2 years |
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