| 货号 | 17527-1mg |
| 描述 | Nicotinic acid adenine dinucleotide phosphate (NAADP) is a dinucleotide second messenger that triggers the release of calcium from lysosomes and related cellular compartments.1trans-Ned-19 is a structural analog of NAADP that blocks NAADP-dependent calcium release (IC50 = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC50 = 0.4 nM).2Thetrans form of Ned-19 is significantly more potent than the cis isomer in both assays.2 Ned-19 does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release.2 It directly binds NAADP receptors on lysosomes in mouse pancreatic beta cells and competitively antagonizes activation by NAADP.2,3 It inhibits glucose-induced calcium oscillations in pancreatic islets and insulin-induced calcium increases in 3T3-L1 adipocytes.2,4 Ned-19 also blocks calcium signaling induced by endothelin-1 or norepinephrine in renal afferent arterioles.5 Ned-19 dose-dependently reduces infection of host cells by Ebola virus.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lam, A.K.M., and Galione, A. The endoplasmic reticulum and junctional membrane communication during calcium signaling. Biochimica et Biophysica Acta 1833(11), 2542-2559 (2013). 2.Naylor, E.,Arredouani, A.,Vasudevan, S.R., et al. Identification of a chemical probe for NAADP by virtual screening. Nature Chemical Biology 5(4), 220-226 (2009). 3.Rosen, D.,Lewis, A.M.,Mizote, A., et al. Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. The Journal of Biological Chemisty 284(50), 34930-34934 (2009). 4.Song, E.K.,Lee, Y.R.,Kim, Y.R., et al. NAADP mediates insulin-stimulated glucose uptake and insulin sensitization by PPARγ in adipocytes. Cell Rep. 2(6), 1607-1619 (2012). 5.Sakurai, Y.,Kolokoltsov, A.A.,Chen, C.C., et al. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science 347(6225), 995-998 (2015). 6.Thai, T.L.,Churchill, G.C., and Arendshorst, W.J. NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles. Am.J.Physiol.Renal.Physiol. 297(2), F510-F516 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 514.6 |
| 分子式 | C30H31FN4O3 |
| CAS号 | 1354235-96-3 |
| 稳定性 | ≥ 2 years |
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