AI-10-49
货号：
17508-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 17508-1mg |
| 描述 | AI-10-49 is an inhibitor that binds the transcription factor fusion CBFβ-SMMHC (core binding factor β and smooth muscle myosin heavy chain) and blocks its binding to the transcription factor RUNX1 (IC50 = 260 nM by FRET).1 It restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Illendula, A.,Pulikkan, J.A.,Zong, H., et al. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science 347(6223), 779-784 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 660.5 |
| 分子式 | C30H22F6N6O5 |
| CAS号 | 1256094-72-0 |
| 稳定性 | ≥ 2 years |
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