| 货号 | 17502-1mg |
| 描述 | Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins.1,2 It is much less effective or without effect against a panel of 229 other kinases.1 Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.1,2 It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme.3 Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Golding, S.E.,Rosenberg, E.,Valerie, N., et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Molecular Cancer Therapeutics 8(10), 2894-2902 (2009). 2.Golding, S.E.,Rosenberg, E.,Adams, B.R., et al. Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control. Cell Cycle 11(6), 1167-1173 (2012). 3.Biddlestone-Thorpe, L.,Sajjad, M.,Rosenberg, E., et al. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. Clinical Cancer Research 19(12), 3189-3200 (2013). 4.McCabe, N.,Hanna, C.D.,Walker, S.M., et al. Mechanistic rationale to target PTEN-deficient tumour cells with inhibitors of the DNA damage response kinase ATM. Cancer Research [Epub ahead of print], 1-2 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 547.7 |
| 分子式 | C30H33N3O5S |
| CAS号 | 925701-46-8 |
| 稳定性 | ≥ 2 years |
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