| 货号 | 17418-1mg |
| 描述 | Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation.1,2 BMS 493 is a pan-RAR inverse agonist that blocks RARα activity with an IC50 value of 114 nM.3,4 In all RAR types (RARα, RARβ, and RARγ), BMS493 prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.5,6 BMS 493 has been used to elucidate the critical roles of RARs in development and immune response.3,7,8,9 |
| 别名 | BMS 204493; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Duong, V., and Rochette-Egly, C. The molecular physiology of nuclear retinoic acid receptors. From health to disease. Biochimica et Biophysica Acta 1812(8), 1023-1031 (2011). 2.Rochette-Egly, C., and Germain, P. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Nuclear Receptor Signaling 7, 1-18 (2009). 3.Chazaud, C.,Chambon, P., and Dollé, P. Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development 126(12), 2589-2596 (1999). 4.García-Rodríguez, J.,Pérez-Rodríguez, S.,Ortiz, M.A., et al. Inhibition of I k B kinaseβ and I k B kinase-α by heterocyclic adamantyl arotinoids. Bioor.Med.Chem. 22(4), 1285-1302 (2014). 5.le Maire, A.,Teyssier, C.,Erb, C., et al. A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor. Nature Structural & Molecular Biology 17(7), 801-807 (2010). 6.Germain, P.,Gaudon, C.,Pogenberg, V., et al. Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists. Chemistry & Biology 16(5), 479-489 (2009). 7.Mollard, R.,Ghyselinck, N.B.,Wendling, O., et al. Stage-dependent responses of the developing lung to retinoic acid signaling. International Journal of Developmental Biology 44(5), 457-462 (2000). 8.Chazaud, C.,Dollé, P.,Rossant, J., et al. Retinoic acid signaling regulates murine bronchial tubule formation. Mech.Dev. 120(6), 691-700 (2003). 9.Geissmann, F.,Revy, P.,Brousse, N., et al. Retinoids regulate survival and antigen presentation by immature dendritic cells. Journal of Experimental Medicine 198(4), 623-634 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 404.5 |
| 分子式 | C29H24O2 |
| CAS号 | 215030-90-3 |
| 稳定性 | ≥ 2 years |
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