| 货号 | 17401-25g |
| 描述 | Phytol is a diterpene alcohol obtained from the degradation of chlorophyll and has been used in the synthesis of Vitamins E and K. During the digestion process of ruminants, phytol is liberated from chlorophyll and converted to phytanic acid (Item No. 90360) to be stored in fats. While humans cannot derive phytol from chlorophyll, free phytol, obtained from the consumption of ruminant adipose tissue and dairy products, is readily absorbed in the small intestine and converted to phytanic acid.1 Phytanic acid accumulates to toxic levels in a number of metabolic disorders, and the conversion of phytol to phytanic acid has been shown to be regulated via the activation of peroxisome proliferator-activated receptor α (PPARα).2,1 Phytol and its metabolites have also been reported to activate retinoid X receptors (RXRs; Kis range from 2.3-67.2 µM) and to promote the activity of PPAR/RXR heterodimers.3,2 Phytol also demonstrates sedative and anxiolytic effects through interaction with the GABAA receptor, and it has been explored as an antischistosomal agent in a mouse model of schistosomiasis.4,5 |
| 别名 | trans-Phytol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gloerich, J.,van den Brink, D.M.,Ruiter, J.P.N., et al. Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation. Journal of Lipid Research 48(1), 77-85 (2007). 2.Elmazar, M.M.,El-Abhar, H.S.,Schaalen, M.F., et al. Phytol/Phytanic acid and insulin resistance: Potential role of phytanic acid proven by docking simulation and modulation of biochemical alterations. PLoS One 8(1), 1-10 (2013). 3.Kitareewan, S.,Burka, L.T.,Tomer, K.B., et al. Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. Molecular Biology of the Cell 7(8), 1153-1166 (1996). 4.Costa, J.P.,de Oliveira, G.A.,de Almeida, A.A., et al. Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission. Brain Research 1547, 34-42 (2014). 5.de Moraes, J.,de Oliveira, R.N.,Costa, J.P., et al. Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropical disease Schistosomiasis mansoni. PLoS One 8(1), 1-12 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥85% (mixture of isomers) |
| 计算分子量 | 296.5 |
| 分子式 | C20H40O |
| CAS号 | 150-86-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |